2021 Fiscal Year Final Research Report
Establishment of detection systems for minimum residual diseases of mature lymphoid malignancies using flow cytometry
Project/Area Number |
19K07903
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52010:General internal medicine-related
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Research Institution | National Cancer Center Japan |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | フローサイトメトリー / 微小残存病変 / 悪性リンパ腫 / 慢性リンパ性白血病 |
Outline of Final Research Achievements |
Recent advances in the treatment for chronic lymphocytic leukemia (CLL) have been able to reduce the count of CLL cells in the peripheral blood after the treatment, that routine laboratory tests cannot detect. As a result, the parameters that have the ability to evaluate the minimal residual disease (MRD) of CLL are required. The aim of this study is to develop the MRD evaluation system for Japanese CLL patients using flow cytometric analysis, that is rapid and inexpensive. The sensitivity has been proved to be 4-log for typical CLL cases, however that for atypical cases has been imprecise and needs to be improved.
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Free Research Field |
臨床検査学
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Academic Significance and Societal Importance of the Research Achievements |
西欧では、CLLのFCMを利用したMRD評価法の統一化が図られています。一方、アジアではCLLは欧米に比し比較的に稀で、また非典型例の割合が高いと報告されており、西欧で認められるCLLと同一の疾患でない可能性があります。日本におけるCLLの治療効果や予後の判定のためには日本人に合わせたMRD評価法を開発することが重要であると考え、本研究を行いました。今回の検討では非典型的な症例の評価を行うには不十分と考えられましたが、今後改善を加えながらより良いものにしていきたいと考えております。
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