2021 Fiscal Year Final Research Report
Study on antigen-positive red blood cells transfusion for the patients who have corresponding irregular RBC antibodies
| Project/Area Number |
19K07935
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52010:General internal medicine-related
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
太田 千亜希 (山田) 浜松医科大学, 医学部附属病院, 臨床検査技師 (60770980)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 不規則抗体 / 遅発性副反応 / 抗原陽性輸血 |
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| Outline of Final Research Achievements |
In all, 826 cases containing 878 antibodies were registered from 45 institutions. The main reasons for antigen-positive RBC transfusions included‘negative by indirect antiglobulin test' (39%) and ‘detection of warm auto-antibodies’(25%). In 23 cases, some adverse reactions were observed after antigen-positive RBC transfusion, and 25 antibodies (9 of 119 clinically significant and 16 of 646 insignificant antibodies) were detected. Non-specific warm autoantibodies were detected in 9 cases, anti-E in 5 cases, 2 cases each of anti-Lea, anti-Jra or cold alloantibodies, and 1 case each of anti-Dib
, anti-Leb or anti-P1. Other antibodies were detected in 2 further cases. Five (22%) of these 23 cases, who had anti-E (3 cases) or anti-Jra (2 cases), experienced clinically apparent haemolysis. Adverse reactions, especially haemolysis, were more frequently observed in cases with clinically significant antibodies than those with clinically insignificant antibodies (P < 0.001).
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| Free Research Field |
輸血学
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| Academic Significance and Societal Importance of the Research Achievements |
緊急時等で不規則抗体が検出された場合、やむをえず、抗原陽性血が輸血される場合があるが、その原因を明らかにできた。実際に、抗原陽性輸血が施行された場合、副反応が心配されるが、その頻度と、臨床的意義のある抗体、臨床的意義の少ない抗体との関係が明らかになった。
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