Establishment of a new treatment for dementia by regeneration associate cells.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K07946
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Tokai University
• Principal Investigator: IMAZEKI Ryoko 東海大学, 医学部, 講師 (10328122)
• Co-Investigator(Kenkyū-buntansha): 永田 栄一郎 東海大学, 医学部, 教授 (00255457) ; 浅原 孝之 東海大学, 医学部, 客員教授 (20246200) ; 瀧澤 俊也 東海大学, 医学部, 教授 (70197234)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 再生アソシエイト細胞 / 血管性認知症 / 慢性脳虚血 / 血管内皮前駆細胞 / 認知症

Outline of Final Research Achievements

We aim to develop new therapies for vascular dementia.We used a chronic mouse ischemic model as vascular dementia model, and transplant the regeneration-associated cells (RACs) which contains high proliferative vascular endothelial progenitor cells to those mice via a mouse caudal vein. A space working memory test and tissue protection effect were evaluated at four weeks (short-term evaluation) and eight months (long-term evaluation) after the transplantation. On the 10 weeks of age female mice, space working memory test was improved and tissue protection effect was observed during short-term evaluation although there were no significant difference on 40 weeks of age female mice and the 10 weeks of age male.
It is necessary to investigate the optimal number of doses and the timing of administration to be injected to vascular dementia model mice.

Free Research Field

脳神経内科学

Academic Significance and Societal Importance of the Research Achievements

現在、認知症の根治療法は確立されておらず、今後、高齢化社会となる本邦において、認知症治療法の開発は、患者や家族の負担軽減のみならず、国家財政の観点からも急務である。本研究において、我々が独自に開発した、再生アソシエイト細胞（血管内皮前駆細胞分化動態及び血管再生・修復能の高い細胞群）を血管性認知症動物モデルに投与し、空間作業記憶の改善や組織保護効果を得たことは、今後、再生アソシエイト細胞投与は、ヒトの血管性認知症治療法につながる可能性を示唆した。本研究の進展は、学術的意義のみならず、社会的意義も大きいと言える。