2022 Fiscal Year Final Research Report
Development of in vitro myelination model of human peripheral nurve
| Project/Area Number |
19K07986
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52020:Neurology-related
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Mika Suga (岸本三佳) 国立研究開発法人理化学研究所, バイオリソース研究センター, 開発研究員 (00340448)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | iPS細胞 / 末梢神経 / シュワン細胞 |
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| Outline of Final Research Achievements |
Development of an in vitro model of myelinated nerves in the human peripheral nervous system is expected for pathological research and drug discovery research on myelination disorders and demyelinating diseases of peripheral nerves.In this study, in order to establish a method for inducing Schwann cells from human iPS cells with high efficiency, we constructed a master gene expression system that directly convert into Schwann cells from human iPS cells.
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| Free Research Field |
幹細胞生物学
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| Academic Significance and Societal Importance of the Research Achievements |
ヒトの末梢神経において軸索の髄鞘（ミエリン）を構成するシュワン細胞の成熟化と髄鞘形成を制御する分子機構は解明されていない。ヒトiPS細胞からシュワン細胞をin vitro で高効率に誘導する方法を確立することにより、シュワン細胞の成熟化と髄鞘形成を制御する分子機構の解明、ヒトの末梢神経の髄鞘形成障害や脱髄疾患の病態解析と治療法開発に資する。
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