Clinical neuropathological study on the associated neurological/psychiatric symptoms and the responsible lesion in argyria granule dementia

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K07988
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52020:Neurology-related
• Research Institution: Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology (2020-2022); National Center of Neurology and Psychiatry (2019)
• Principal Investigator: Saito Yuko 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究部長 (60344066)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: パーキンソニズム / タウオパチー / 高齢者 / 認知症

Outline of Final Research Achievements

Immunohistochemical investigation of the possibility that nigrostriatal dopaminergic neuron dysfunction in AGD may be the cause of parkinsonism (PA). AGD group with PA and dementia (DGP), AGD group with dementia and no PA (DG), normal control (NC) group, Parkinson's disease (PD) group, and PSP group. Immunostaining was performed. Evaluation using anti-tyrosine hydroxylase antibody and anti-dopamine transporter antibody. Brainstem cross-sections including the substantia nigra showed argyrophilic granules mainly in the substantia nigra in the DGP group, but not in the DG group. The striatum-positive fiber density was significantly decreased by DGD in the AGD group compared to NC. PA in AGD may be due to hypofunction of nigrostriatal dopaminergic neurons.

Free Research Field

神経病理

Academic Significance and Societal Importance of the Research Achievements

パーキンソニズムの原因として、嗜銀顆粒も関与することが明らかとなた。パーキンソニズムの病態を知るうえで、また、薬剤反応性の悪い群にこのような例が存在することが明らかとなった。