2021 Fiscal Year Final Research Report
The mechanism of T cell-mediated B cell activation in multiple sclerosis and its clinical significance
Project/Area Number |
19K07990
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52020:Neurology-related
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Research Institution | Teikyo University (2020-2021) The University of Tokyo (2019) |
Principal Investigator |
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 多発性硬化症 / 濾胞性ヘルパーT細胞 / B細胞 / 遺伝子発現解析 |
Outline of Final Research Achievements |
B cell activation has recently been implicated as a factor incrementing the disease activity of multiple sclerosis. Follicular helper T cell (Tfh)is a cell with high potential in activating B cells. In our research, applying next generation sequencing method, we have analyzed the gene expression profile of Tfh cells sorted by flow cytometry from peripheral blood monocytes of relapsed MS patients. Among the genes significantly up-regulated in Tfh cells of relapsed patients, we found a molecule related to TGF-b signaling pathway as a candidate biomarker involved in promoting MS disease activity.
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Free Research Field |
神経免疫学
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Academic Significance and Societal Importance of the Research Achievements |
多発性硬化症(MS)の病態機序は均一でなく異質性が存在すると考えられている。治療法に対する反応性も異なり、免疫学的機序を反映した疾患活動性マーカーに基づいた治療アルゴリズムの構築が待たれる。本研究でB細胞の活性化機序の一端を担う濾胞性ヘルパーT細胞(Tfh)においてMS再発時にTGF-βシグナル伝達関連分子の遺伝子発現が亢進していることが明らかになり、Tfh細胞に発現している本分子がMSの一群の免疫学的機序を反映した疾患活動性並びに治療反応性マーカーとなる可能性が考えられ、今後MS治療アルゴリズム構築への貢献が期待される。
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