Influence of deep and subcortical white matter lesions on pathophysiology of Insomnia disorder

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08016
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: National Center of Neurology and Psychiatry
• Principal Investigator: Kuriyama Kenichi 国立研究開発法人国立精神・神経医療研究センター, 精神保健研究所 睡眠・覚醒障害研究部, 部長 (00415580)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 不眠症 / 身体症状症 / 疼痛性障害 / 大脳白質病変

Outline of Final Research Achievements

The deep and subcortical white matter lesion volume of 46 patients with chronic insomnia was calculated. It showed a significant correlation between insomnia severity and the deep and subcortical white matter lesion volume. When insomnia patients with comorbid obstructive sleep apnea (OSA) were analyzed separately, significant positive correlations were found in both the insomnia and OSA comorbid groups, with the OSA comorbid group showing stronger correlations.

Free Research Field

精神医学、睡眠医科学

Academic Significance and Societal Importance of the Research Achievements

不眠症の病態に大脳深部白質病変の影響は強く、白質病変の主たる原因である虚血性変化のリスク因子（OSA等）を有する場合、不眠症の器質基盤が強化されることが推察された。不眠症の発症・増悪を防止するには、虚血性変化を促進し得る疾患の発症・増悪を予防する医学的介入の重要性が示唆された。