2023 Fiscal Year Final Research Report

Epidemiological research into developmental disorders in 3-year-old children and development of new diagnostic tools for early detection.

Research Project

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Project/Area Number	19K08035
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52030:Psychiatry-related
Research Institution	Hirosaki University
Principal Investigator	Mikami Tamaki 弘前大学, 保健学研究科, 助教 (40400501)
Co-Investigator(Kenkyū-buntansha)	斉藤まなぶ弘前大学, 保健学研究科, 教授 (40568846) 中村和彦弘前大学, 医学研究科, 教授 (80263911) 大里絢子弘前大学, 医学研究科, 助教 (80597162) 新川広樹弘前大学, 医学研究科, 特任助教 (10848295)
Project Period (FY)	2019-04-01 – 2024-03-31
Keywords	3歳児健診 / 神経発達症 / スクリーニングツール
Outline of Final Research Achievements	The estimated prevalence of autism spectrum disorder was calculated using the SRS-2 infant version and the PARS-TR abbreviated version for participants in the City A 3-year-old health check (total of 2264 people), and the estimated prevalence of ASD was estimated to be 2.8%. A preliminary survey of the city's 3-year-old developmental health check showed that the combination of the SRS-2 interpersonal response scale and the SDQ children's strengths and difficulties questionnaire was statistically valid for extracting children who may have neurodevelopmental disorders, and a new scale was developed by extracting items specialized in social development through statistical analysis from a total of 85 questions by adding the SDQ to the SRS-2 (sensitivity 82.8%, specificity 96.8%, AUC 0.98, 11.4% of subjects for detailed examination). In addition, a prototype of a 3-year-old developmental health check web system was developed and is currently being used in City A 3-year-old health checks.
Free Research Field	小児科学
Academic Significance and Societal Importance of the Research Achievements	国内の乳幼児健診での発達障害の早期発見は、専門家の不足や健診スタッフのマンパワー不足などにより社会実装が難しい状況にある。3歳児発達健診における本スクリーニングが社会実装されれば、専門家が不足している地域の3歳児発達健診での活用が可能となり、発達特性を持つ児への早期発見と早期介入が期待される。また、本研究で開発した３歳児発達健診WEBシステムは他地域においても活用が可能となったため、発達健診における健診スタッフの労力削減が期待できる。この点から社会的意義は十分果たせるものと言える。