Pathomechanisms of neuropsychiatric disorders associated with tripartite synaptic transmission

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08073
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52030:Psychiatry-related
• Research Institution: Mie University
• Principal Investigator: Okada Motohiro 三重大学, 医学系研究科, 教授 (10281916)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 認知機能 / 情報伝達 / 神経 / グリア / 病態生理

Outline of Final Research Achievements

Mediodorsal thalamic nucleus receives monoaminergic projections from midbrain and also various sensory inputs.
The improvement of input efficiency and/or output efficiency of the thalamocortical transmission contributed to regulation of cognitive integration and improvement of executive function. Neurotransmission played important roles in the regulation of transmission in milliseconds orders, but glial transmission in regulated that in several day orders. Connexin, which expresses in astrocytes, also provided the regulation mechanisms of long-term astroglial transmissions.

Free Research Field

精神薬理

Academic Significance and Societal Importance of the Research Achievements

認知機能の中で、知覚統合と遂行機能は少なくとも短期的機能制御機構は神経伝達が担っているが、これらの長期的な制御には、グリア伝達が制御を担っており、神経とグリアの情報伝達としてのtripartite synaptic transmissionが、認知機能制御に重要な役割を果たしている可能性を示すことが出来た。この知見は、従来の診断分類に従った病態解明研究ではなく、機能的な障害による障害分類に基づいた病態生理解析に有用性を示すものである。