2021 Fiscal Year Final Research Report
Endophenotype integrated analysis of brain imaging and cognitive function in adolescent obsessive-compulsive disorder.
| Project/Area Number |
19K08076
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52030:Psychiatry-related
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中尾 智博 九州大学, 大学病院, 講師 (50423554)
樋渡 昭雄 九州大学, 医学研究院, 准教授 (30444855)
山下 洋 九州大学, 大学病院, 学術研究員 (20253403)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 強迫性障害 / エンドフェノタイプ / 脳画像研究 / 神経心理機能 / 脳大域ネットワーク / 安静時機能的MRI / 反応抑制障害 / 小脳 |
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| Outline of Final Research Achievements |
The aim of this study was to investigate whether patients with obsessive-compulsive disorder in childhood and adolescence and their relatives have abnormalities in similar intrinsic brain networks. However, the recruitment of child and adolescent patients and their relatives did not proceed, and the number of the subjects required for imaging and neuropsychological test analysis was not reached. Therefore, we investigated whether there were abnormalities in the intrinsic brain network and neuropsychological functions in adult patients with OCD and their relatives.
The results revealed that not only OCD patients but also their relatives had common abnormalities in their intrinsic brain networks. In addition, we found that cognitive dysfunction in OCD patients is related to abnormalities in the large intrinsic brain networks.
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| Free Research Field |
強迫性障害の病因解明
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| Academic Significance and Societal Importance of the Research Achievements |
強迫性障害は脳の線条体や眼窩前頭皮質、視床といった部位がその病態に強く関与していることが報告されてきた。近年では、脳の様々な部位が機能的に結合し、いくつかの大域的なネットワークを構成していることが分かっている。本研究では、強迫性障害の患者がその脳ネットワークに異常があるということに加えて患者の家族にもそのような異常があることを明らかにした。つまり、脳ネットワークの異常が強迫性障害のエンドフェノタイプ（中間表現型）であることを示唆することができたといえる。
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