Cancer Targeting and Microenvironment Control by Combination of IVR and Nanomedicine

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08118
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Kanazawa University
• Principal Investigator: KODA Wataru 金沢大学, 医学系, 准教授 (30401920)
• Co-Investigator(Kenkyū-buntansha): 小林 聡 金沢大学, 保健学系, 教授 (30313638)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: IVR / ナノ粒子 / 担体 / フィブリン糊

Outline of Final Research Achievements

We performed basic experiments to develop a treatment combining IVR and nanoparticles to synergistically amplify anticancer activity while reducing side effects and showed that fibrin glue could be used as a carrier to directly and efficiently deliver nanoparticles to target tissues using IVR techniques. We also showed that cooling the fibrin glue controlled the rate of gelation and provided a delayed reaction effect suitable for clinical use.

Free Research Field

放射線医学

Academic Significance and Societal Importance of the Research Achievements

ナノメディシンとIVRを組み合わせ治療の基礎実験を進めることにより、副作用を軽減しながら相乗的に抗癌作用を増幅させる新たな低侵襲がん局所治療法の開発に繋がることが期待される。また、臨床使用に適したフィブリン糊の作成方法を確立することで、担体としての利用以外にも様々な応用が可能になることが期待される。