2021 Fiscal Year Final Research Report
Prospective evaluation of impact of Calcium score in lower extremity on clinical outcomes after endovascular treatment
| Project/Area Number |
19K08159
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大林 賢史 奈良県立医科大学, 医学部, 特任准教授 (30596656)
市橋 成夫 奈良県立医科大学, 医学部, 学内講師 (60597102)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 血管内治療 / 下肢閉塞性動脈硬化症 |
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| Outline of Final Research Achievements |
In this study, 102 patients who received endovascular treatment for arteriosclerotic occlusive lesions of the femoral popliteal artery from January 2018 to the end of December 2020 were analyzed. The median calcium score was 2807. A relatively strong correlation was found between the PACSS score and the calcium score measured by CT (correlation coefficient 0.67 P <0.001). The primary patency rate (restenosis avoidance rate) at the treatment site was 88% and 74% in 1 to 2 years. The risk factors for restenosis by univariate analysis were only in dialysis patients (HR4.225, 1.701-10.492, P = 0.002), and the PACSS score and the calcium score on CT were not significant.
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| Free Research Field |
血管内治療
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| Academic Significance and Societal Importance of the Research Achievements |
本応募研究では2018年1月から2020年12月末までに大腿膝窩動脈の動脈硬化性閉塞性病変に血管内治療を受けた102名を分析対象とした。石灰化を客観的に定量化したカルシウムスコア中央値は2807だったが、カルシウムスコアは血管内治療成績の良し悪しを予測するものではなかった。むしろ石灰化の分布に着目した研究が重要と考えられる。石灰化分布と治療成績との関係が明らかになれば、治療成績向上を狙った治療戦略アルゴリズム構築に寄与するものと期待される。
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