Quantitative assessment of bone marrow activity using 18F-FLT PET in bone marrow failure syndrome

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08170
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: University of Fukui
• Principal Investigator: Tsujikawa Tetsuya 福井大学, 高エネルギー医学研究センター, 准教授 (30380033)
• Co-Investigator(Kenkyū-buntansha): 細野 奈穂子 福井大学, 学術研究院医学系部門(附属病院部), 講師 (50509312) ; 森 哲也 福井大学, 高エネルギー医学研究センター, 助教 (40397287)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: FLT / PET/MRI / 骨髄不全症

Outline of Final Research Achievements

FLT SUVs were significantly correlated with bone marrow cell numbers and cell density. Significant positive correlations between iliac and vertebral SUVs were found in AA and MDS, and a significantly steeper slope of the regression line was found in AA than in MDS.　In AA patients, vertebral FLT SUVs significantly decreased as the disease progressed, and in MDS patients, higher whole-body FLT uptake was an indicator of shorter overall survival.
Quantitative whole-body bone marrow imaging using FLT PET helps distinguish aplastic anemia from myelodysplastic syndromes, assess severity of aplastic anemia and prognosis of myelodysplastic syndromes.

Free Research Field

核医学

Academic Significance and Societal Importance of the Research Achievements

日常臨床で骨髄を評価する際に腸骨から骨髄穿刺や骨髄生検を行うが、これらは侵襲的であると同時に、サンプリングエラーや検体が全身骨髄を反映していない場合がある。FLT PET検査は非侵襲的に全身の骨髄活性を定量化できるため、骨髄不全症候群においてその鑑別診断、重症度判定や予後予測に有用である可能性がある。