2022 Fiscal Year Final Research Report

Development of imaging methods to predict genomic and molecular abnormalities for personalized treatment of biliary tract cancer.

Research Project

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Project/Area Number	19K08176
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Oita University
Principal Investigator	Asayama Yoshiki 大分大学, 医学部, 教授 (40380414)
Co-Investigator(Kenkyū-buntansha)	西江昭弘九州大学, 医学研究院, 教授 (20457427) 石松慶祐九州大学, 大学病院, 医員・臨床助教 (20800147) 牛島泰宏九州大学, 大学病院, 講師 (40432934) 高山幸久九州大学, 大学病院, 助教 (60546563) 中山智博九州大学, 医学研究院, 講師 (70419571)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	胆道癌 / computed tomography
Outline of Final Research Achievements	First, we investigated the optimal reconstruction method of CT cholangiography for the evaluation of biliary tract cancer in ultra-high resolution CT. The reconstruction methods used were AiCE (Advanced intelligent Clear-IQ Engine), FIRST (Forward projected model-based Iterative Reconstruction SoluTion), and AIDR (Adaptive Iterative Dose Reduction)-3D, of which AiCE was the best. Next, we examined the optimal reconstruction method for CT using low-iodine contrast media in patients with poor renal function. The AiCE reconstruction method was superior to the conventional method.
Free Research Field	放射線医学
Academic Significance and Societal Importance of the Research Achievements	胆道癌は分子標的薬での治療が可能となることが将来期待されるが、手術以外に十分な検体を取得することが困難な腫瘍である。早期診断や適切な治療薬選択、予後予測が画像により可能となれば、予後延長、医療費削減に役立つ。本研究は胆道癌の画像診断を支える基本的診断技術を高めるものである。