2022 Fiscal Year Final Research Report

Development of the 18F-FDG PET Ki parametric images for evaluation of the disease activity in cardiac sarcoidosis

Research Project

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Project/Area Number	19K08178
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Kagoshima University
Principal Investigator	Nakajo Masatoyo 鹿児島大学, 医歯学域医学系, 講師 (00594631)
Co-Investigator(Kenkyū-buntansha)	窪薗琢郎鹿児島大学, 医歯学域医学系, 講師 (00598013) 吉浦敬鹿児島大学, 医歯学域医学系, 教授 (40322747) 神宮司メグミ鹿児島大学, 医歯学域鹿児島大学病院, 助教 (70418862) 谷淳至鹿児島大学, 医歯学域鹿児島大学病院, 講師 (70788166)
Project Period (FY)	2019-04-01 – 2023-03-31
Keywords	心サルコイドーシス / 18F-FDG PET/CT / Ki parametric image
Outline of Final Research Achievements	We investigated the usefulness of Ki parametric images extracted from dynamic 18F-FDG-PET/CT for evaluating the risk of clinical events (CEs) in cardiac sarcoidosis (CS). The Ki parametric images were generated from 30 dynamic 18F-FDG-PET/CT scans of 21 CS patients. The Ki images were rated as positive in 19 scans and negative in 11 scans, and the incidences of CEs were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11); arrhythmic events: 65.5% (10/19) vs. 0% (0/11)]. In 19 positive scans, 3 Ki parameters (Ki max, Ki mean and Ki volume) were significantly higher in patients with arrhythmic events than in those without them. Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events. These results suggest that Ki images may add value to SUV images for evaluating the risk of CEs in CS patients.
Free Research Field	放射線診断学
Academic Significance and Societal Importance of the Research Achievements	サルコイドーシスは原因不明の全身性肉芽腫疾患である。心臓病変(心サルコイドーシス)は致死性不整脈や重症心不全を来たし、また、突然死の原因ともなり、サルコイドーシス患者の予後を大きく左右する。18F-FDG-PETは診断感度の向上に寄与することが明らかになっているが、心筋への生理的な集積の影響により、従来の18F-FDG-PET画像(SUV 画像)では活動性評価が困難な場合がある。今回の研究で、組織への18F-FDGの移行状態を反映したKi パラメトリック画像は新たな心サルコイドーシスの活動性評価法となり、患者の治療や管理の上で有用な情報を提供することが示唆された。