Effect of amnion-derived mesenchymal stem cells for the treatment of radiation-induced oral mucositis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08192
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: Hokkaido University
• Principal Investigator: Yuki Satoshi 北海道大学, 大学病院, 助教 (80455633)
• Co-Investigator(Kenkyū-buntansha): 大西 俊介 北海道大学, 医学研究院, 准教授 (10443475)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 放射線性口内炎

Outline of Final Research Achievements

The aim of this study was to investigate the effect of amnion-derived mesenchymal stem cells (AMSCs) for the treatment of radiation-induced oral mucositis.
We prepared conditioned medium from AMSCs, and applied the conditioned medium on the tongue after irradiation. Body weight loss was slightly improved by the treatment, but there was no statistical significance. Pathological score was not improved by the treatment, and the expressions of several inflammatory cytokines were not improved by the treatment.

Free Research Field

癌化学療法

Academic Significance and Societal Importance of the Research Achievements

頭頸部がんに対する放射線治療の合併症としてしばしば発症する放射線性口内炎の新規治療法の開発を目的として、羊膜間葉系幹細胞に着目し、その培養上清を放射線性舌炎モデルラットの舌に塗布するという方法で効果を検討したが、明らかな効果が認められなかった。動物モデルと実臨床での病態の違いや、培養上清に含まれる有効成分の濃度の低さなどが関係しているかもしれず、今後の検討課題である。