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2021 Fiscal Year Final Research Report

Boron distribution study for newly developed BNCT agents

Research Project

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Project/Area Number 19K08194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionUniversity of Tsukuba

Principal Investigator

Nakai Kei  筑波大学, 医学医療系, 准教授 (50436284)

Co-Investigator(Kenkyū-buntansha) 吉田 文代  筑波大学, 医学医療系, 研究員 (30261811)
中村 浩之  東京工業大学, 科学技術創成研究院, 教授 (30274434)
白川 真  福山大学, 薬学部, 講師 (40707759)
松本 孔貴  筑波大学, 医学医療系, 助教 (70510395)
鶴淵 隆夫  筑波大学, 医学医療系, 講師 (70778901)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsホウ素中性子捕捉療法 / アルファ線 / リポソーム
Outline of Final Research Achievements

1. Regarding the tumor growth inhibitory effect of intravascular boron, the non-leakage Liposome group showed almost the same tumor growth as the irradiation alone group, suggesting that boron in the blood contributes little to tumor growth inhibition even by neutron irradiation. This may be due to the fact that particle beams do not reach the vascular endothelium in blood vessels more proximal than capillaries, or the degree of damage is not strong enough to block blood flow.
2. In the visualization of boron distribution using CR39, alpha rays generated in the range of 5-10 micrometers from the CR39 surface can be visualized in cells attached to CR39. Based on this result, it is considered possible to estimate the intracellular boron distribution.

Free Research Field

放射線腫瘍学、粒子線治療

Academic Significance and Societal Importance of the Research Achievements

本結果をさらに発展させることによって、まず、ホウ素動態の細胞、間質における詳細を検討することが可能となり、また、領域ごとのホウ素濃度を加減して照射実験を行うことで、その効果を評価することが可能となる。その結果を詳細に検討することで、BNCT用の新規ホウ素薬剤の開発コンセプトを明確にすることができる。

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Published: 2023-01-30  

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