A study of the diversity of radiosensitivity in chemoresistant malignant lymphomas

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08219
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: University of Tsukuba
• Principal Investigator: Tamaki Yoshio 筑波大学, 医学医療系, 客員研究員 (60188422)
• Co-Investigator(Kenkyū-buntansha): 小島 寛 筑波大学, 医学医療系, 教授 (10225435) ; 水本 斉志 筑波大学, 医学医療系, 准教授 (20512388)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 悪性リンパ腫 / 放射線感受性 / 化学療法抵抗性

Outline of Final Research Achievements

The effect of radiotherapy for follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) that remained or relapsed after chemotherapy was analyzed. All of 6 cases with FL had complete remission (CR) after radiotherapy, and one had recurrence in the field of radiotherapy. The response among 12 cases of DLBCL was CR:9, PR/SD:3. Three of 5 cases with GCB (germinal B-cell) type had CR, while all of 5 with non-GCB type had CR. Relapse after CR was observed in 2 with non-GCB type. These results suggest that cell of origin is a useful predictor of therapeutic efficacy in radiotherapy for chemorefractory DLBCL.

Free Research Field

放射線治療

Academic Significance and Societal Importance of the Research Achievements

化学療法抵抗性のB細胞性リンパ腫の放射線感受性について、その生物学的背景との関連性に言及した報告は乏しかった。今回の研究成果から、びまん性大細胞性B細胞リンパ腫（DLBCL）のcell of originが、化学療法抵抗性DLBCLの放射線治療効果の予測因子になることが示唆された。本研究の成果が、DLBCLの分子病理学的背景や遺伝子異常と放射線感受性の関係に関する研究を進展させる契機となることを期待する。