New therapy for neonatal resuscitation using hydrogen gas

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K08253
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52050:Embryonic medicine and pediatrics-related
• Research Institution: Kagawa University
• Principal Investigator: NAKAMURA SHINJI 香川大学, 医学部附属病院, 助教 (30437686)
• Co-Investigator(Kenkyū-buntansha): 安田 真之 香川大学, 医学部附属病院, 准教授 (00380155) ; 小谷野 耕佑 香川大学, 医学部附属病院, 講師 (20437685) ; 三木 崇範 香川大学, 医学部, 教授 (30274294) ; 上野 正樹 香川大学, 医学部, 教授 (30322267) ; 日下 隆 香川大学, 医学部, 教授 (50274288) ; 太田 健一 香川大学, 医学部, 助教 (50403720)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 水素ガス / 低酸素性虚血性脳症 / 新生仔豚

Outline of Final Research Achievements

In this study, to verify the brain protective effect of short-term hydrogen gas inhalation, HI loading was performed on 16 neonatal piglets within 24 hours of birth, and after resuscitation, the piglets were divided into two groups: no treatment group and H2 gas inhalation group. In aEEG, the EEG recovery time was defined as the time from the end of Low Amplitude EEG (LAEEG: maximum amplitude < 5 μV) to the end of suppression EEG recovery. The number of neurons in the H2 group was higher than that in the NT group in mild cases. EEG recovery time was significantly shorter in the H2 group than in the NT group in mild cases. Short-time H2gasIT in neonatal piglets suppresses normal neuron loss and speeds up suppression EEG recovery in mild cases.

Free Research Field

新生児

Academic Significance and Societal Importance of the Research Achievements

本研究結果から、水素ガス吸入療法を新生児蘇生で用いることが、新生児低酸素性虚血性脳症の予後改善に寄与する可能性が示唆された。このように周産期領域における予後改善が期待できる本研究の治療法開発は、医学的また社会的にも大きな意義を持つことであると考える。