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2021 Fiscal Year Final Research Report

Biopathological analysis and novel therapy development for pediatric severe acute kidney injury

Research Project

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Project/Area Number 19K08277
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionOkayama University

Principal Investigator

Tsukahara Hirokazu  岡山大学, 医歯薬学域, 教授 (90207340)

Co-Investigator(Kenkyū-buntansha) 宮原 宏幸  岡山大学, 大学病院, 医員 (00807654)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords活性酸素 / 活性窒素 / 急性腎障害 / 細胞機能修飾薬 / 酸化ストレス / 集中治療 / 多臓器障害 / レドックス
Outline of Final Research Achievements

Critically ill pediatric patients are likely to present with acute kidney injury (AKI) or acute renal failure (ARF). In this project, we have obtained data on the use of specific biomarkers of oxidative/nitrosative stress and endothelial function in the pathogenetic mechanisms involved in multiple organ failure, cardiac defects, respiratory/allergic diseases, Kawasaki disease, IgA vasculitis, and renal stone disease. AKI/ARF might develop in these diseases. Reactive oxygen/nitrogen species contribute to the progression and amplification of the pathophysiological responses related to the diseases. Future breakthroughs in this field may provide a promising therapeutic strategy for the prevention and treatment of AKI/ARF in the pediatric patients.

Free Research Field

医学

Academic Significance and Societal Importance of the Research Achievements

感染性、炎症性、腫瘍性疾患はいうに及ばず、呼吸器、消化器、腎血管、内分泌、代謝性疾患などにおいても,“酸化ストレス”は基本病態である。各疾患は急速進行性でも、慢性遷延性でも組織・臓器を廃絶に導く危険性を伴うが、これを防ぐ有効な手段として酸化ストレスの制御は重要である。一方、病状悪化を抑えながら組織・臓器を保護し再生させるためには,“血管内皮機能”を保持することも必要である。今回の3年間の研究では、この方面に特化した研究成果として一定の進展が見られた。

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Published: 2023-01-30  

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