2021 Fiscal Year Final Research Report
Sterile Inflammation - A novel approach to preterm birth -
| Project/Area Number |
19K08331
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52050:Embryonic medicine and pediatrics-related
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| Research Institution | Nippon Medical School |
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Principal Investigator |
SHIMA YOSHIO 日本医科大学, 医学部, 教授 (70714765)
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| Co-Investigator(Kenkyū-buntansha) |
根岸 靖幸 日本医科大学, 医学部, 准教授 (50644580)
桑原 慶充 日本医科大学, 医学部, 准教授 (40373013)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | sterile inflammation / preterm birth |
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| Outline of Final Research Achievements |
Preterm birth remains a major health issue in Japan, despite its high levels of standard care. Infection has been considered as a central role in preterm births and their consequence, however, it is not proven in many cases in practice. The research focused on inflammation evoked by self-component around the perinatal period, with the results that endogenous molecular patterns in placental tissue or clinical specimens from preterm infants activated innate immune system and contributed to pathophysiology.
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| Free Research Field |
周産期医学
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| Academic Significance and Societal Importance of the Research Achievements |
我が国の周産期医療の大きな課題である早産の臨床において、これまでのような感染を中心とした解析や研究では、詳細不明としか分類し得なかった多くの事例に対して、無菌性炎症という新たな視点を与えることで、検査や治療的アプローチについてより幅広い選択肢を提供できる可能性を提言することができた。今後、本研究を基礎とした臨床応用が進められることで、早産そのものの予防や、早産児の予後をさらに改善して国民の福祉に貢献できるものと考えている。
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