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2021 Fiscal Year Final Research Report

Exploration of cellular factors involved in CMV neuropathogenesis in congenital CMV infection

Research Project

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Project/Area Number 19K08335
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionNational Center for Child Health and Development

Principal Investigator

Nakamura Hiroyuki  国立研究開発法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 室長 (70256866)

Project Period (FY) 2019-04-01 – 2022-03-31
Keywordsサイトメガロウイルス / 先天性サイトメガロウイルス感染症 / CMV / 神経障害 / 感覚器障害 / 難聴
Outline of Final Research Achievements

Understanding the molecular neuropathogenesis of congenital cytomegalovirus (CMV) infection is crucial to establishing novel strategies for controlling CMV neuropathogenesis. We established a cellular library in which multiple shRNAs are transduced and expressed to identify novel cellular factors involved in CMV neuropathogenesis. Using the cellular library, we performed a comprehensive screening of shRNAs, which may contribute to the attenuation of CMV neuropathogenesis. Several experiments were conducted to verify the suppressive effects of shRNAs on CMV-mediated cellular damages. Further studies are needed to clarify molecular mechanisms of how identified shRNAs are involved in the suppression of CMV-mediated cellular damages.

Free Research Field

ウイルス学

Academic Significance and Societal Importance of the Research Achievements

先天性CMV感染が引き起こす神経・感覚器障害の発症に関連する細胞因子の同定は、ウイルス因子が細胞因子とどのように関わりながら病原性を発現し発症に至るのかについて理解を深めることにつながると期待される。また、本研究で得られる知見は、CMV病原性発現および神経・感覚器障害発症の抑制を可能にするような治療標的分子の同定につながる可能性もある。当該疾患の神経・感覚器障害の発症メカニズムに基づく新たな制御法開発によって、先天性CMV感染症におけるさまざまな合併症の制御を可能にすることげできれば、先天感染児の成長・発達や予後の改善につなげ得ることが期待される。

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Published: 2023-01-30  

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