Study of the control mechanism of myosin light chain kinase aimed at elucidating the pathogenesis of IBD

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08364
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Saito Eiko 東京医科歯科大学, 東京医科歯科大学病院, 助教 (00406456)
• Co-Investigator(Kenkyū-buntansha): 渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127) ; 鬼澤 道夫 福島県立医科大学, 医学部, 助教 (30783352) ; 永石 宇司 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 炎症性腸疾患

Outline of Final Research Achievements

The barrier dysfunction of the intestinal epithelium, which is caused by upregulation of TNFR2 and activation of myosin light chain kinase in epithelial cells, is involved in the pathogenesis of inflammatory bowel disease. In this study, we analyzed the membrane-type TNF complex and also found a TNF mutant strain that regulates the expression of membrane-type TNF. Based on our study, it will be a new understanding of the pathophysiology of inflammatory bowel disease and the development of new treatments.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

免疫細胞と腸管上皮細胞のクロストーク、すなわちTNFを基点としたTNFR2/ミオシン軽鎖キナーゼ/腸間上皮のバリア機能障害による炎症の持続のメカニズム解明は、炎症性腸疾患のみならず自己免疫疾患全般における新規治療法へ向けた理論、技術基盤の創出に発展するものと期待される。