Study of tight junction regulators for colorectal tumor prevention

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08388
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Masayoshi Fukuda 東京医科歯科大学, 東京医科歯科大学病院, 助教 (00733627)
• Co-Investigator(Kenkyū-buntansha): 渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127) ; 鬼澤 道夫 福島県立医科大学, 医学部, 助教 (30783352) ; 永石 宇司 東京医科歯科大学, 大学院医歯学総合研究科, 寄附講座准教授 (60447464)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 大腸癌

Outline of Final Research Achievements

The number of colorectal cancer patients has increased in Japan. It is difficult to establish an effective preventive method because mechanisms by which diet affects colorectal tumors are largely unknown. In the current study, effects of various amino acids on colon organoids and colon tumor organoids were screened. Their effects were subsequently analyzed in vivo. The results of this research are expected to contribute to an establishment of an effective method to prevent colorectal cancer.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

本邦における大腸癌罹患者数増加してきたが、食餌が大腸腫瘍に及ぼす機序の多くが不明であるため有効な予防法確立を困難にしている。本研究成果は大腸癌予防法の確立へ向けた基盤形成に寄与すると期待できる。