Mechanism and control of collapse of gut microbiota caused by Helicobacter pylori eradication

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K08395
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53010:Gastroenterology-related
• Research Institution: Okayama University
• Principal Investigator: Okada Hiroyuki 岡山大学, 医歯薬学総合研究科, 特命教授 (60263563)
• Co-Investigator(Kenkyū-buntansha): 後藤 和義 岡山大学, 医歯薬学域, 助教 (20626593) ; 横田 憲治 岡山大学, 保健学域, 教授 (00243460) ; 松下 治 岡山大学, 医歯薬学域, 教授 (00209537) ; 田中 健大 岡山大学, 医歯薬学域, 講師 (70549857) ; 岡上 昇太郎 岡山大学, 大学病院, 医員 (20839716)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 腸内細菌叢 / 若年成人 / Helicobacter pylori / 除菌 / α多様性 / dysbiosis

Outline of Final Research Achievements

We aimed to examine changes in the gut microbiota before and after H. pylori eradication in young adults. The stool specimens of the ten patients average 19.8 years were collected before, 2 weeks after, and 2 months after H. pylori eradication. Then, the bacterial composition at the phylum and genus levels and α-diversity were analyzed. No significant changes were observed in the relative abundance of Firmicutes after eradication. Although the number of Proteobacteria increased in five patients 2 weeks after eradication, the altered ratio returned to the former levels after 2 months; dysbiosis was not observed. The α-diversity transiently decreased 2 weeks after eradication in several patients. Additionally, Klebsiella strains transiently increased 2 weeks after eradication and returned to the baseline level after 2 months. We consider that H. pylori eradication can safely be performed even in young adults without concern for dysbiosis of the gut microbiota.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

Helicobacter pylori (H.pylori)除菌は胃癌発症を抑制することが示されている．さらに胃癌発症の母地となる萎縮性胃炎の進行していない青少年期のH.pylori除菌が発症抑制効果が大きいと報告されているが，若年成人における除菌による腸内細菌叢の変化については明らかにされていなかった．今回の研究で若年成人における若年成人除菌はdysbiosisを起こすことなく安全に行うことができることが示された．