2021 Fiscal Year Final Research Report
Visualization of the dynamics of colitogenic memory T cells in vivo
Project/Area Number |
19K08437
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 53010:Gastroenterology-related
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Okada Eriko 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (20376784)
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Co-Investigator(Kenkyū-buntansha) |
渡辺 守 東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127)
根本 泰宏 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (20456213)
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Project Period (FY) |
2019-04-01 – 2022-03-31
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Keywords | 炎症性腸疾患 / メモリーT細胞 / in vivo live imaging |
Outline of Final Research Achievements |
Inflammatory bowel disease (IBD) is characterized by an intractable intestinal inflammation and patients usually need life-long maintenance treatment to prevent their recurrence. In a series of previous studies, we have clarified that colitogenic memory T cells, which survive even in a remission stage, play important roles for the intractability of IBD and they are ultimate target for the radical treatment of IBD without any maintenance treatment. On the other hand, the maintenance system of colitogenic memory T cells are not completely clarified yet. In this study, we have established in vivo live imaging systems to visualize the dynamics of colitogenic memory T cells in the intestinal mucosa and their reservoir organs for the first time. This system will be useful tool to clarify the pathogenesis of IBD and to develop next-generation treatment for IBD targeting colitogenic memory T cells.
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Free Research Field |
消化器内科学
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Academic Significance and Societal Importance of the Research Achievements |
今回の研究において、我々は世界で初めて慢性大腸炎モデルマウスの大腸粘膜およびリンパ組織におけるメモリーT細胞動態の可視化に成功した。本システムは今後のIBD研究のみならず、様々な大腸疾患の研究において有用なツールとなりうる。
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