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2021 Fiscal Year Final Research Report

Genetic profile and biological diversity of colorectal tubular adenoma

Research Project

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Project/Area Number 19K08467
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53010:Gastroenterology-related
Research InstitutionKyoto University

Principal Investigator

Yamada Atsushi  京都大学, 医学研究科, 特定准教授 (20569610)

Co-Investigator(Kenkyū-buntansha) 井上 正宏  京都大学, 医学研究科, 特定教授 (10342990)
鎌田 真由美  京都大学, 医学研究科, 准教授 (70749077)
近藤 純平  京都大学, 医学研究科, 特定助教 (80624593)
Project Period (FY) 2019-04-01 – 2022-03-31
Keywords大腸管状腺腫
Outline of Final Research Achievements

We utilized patient-derived tissue samples of colorectal tubular adenomas and performed organoid culture. We then separate colorectal adenoma-derived organoids into single cells and assessed their ability to grow as spheroids. As a result, single-cell spheroid forming and growth assay revealed the diversity of tubular adenomas in terms of proliferation capacity as spheroids when cultured single cells. In addition, because the diverse ability of tubular adenomas to growth as spheroids was retained after repeated single cell culture of single cell-derived spheroids, the spheroid proliferation capacity of colorectal tubular adenoma is suggested to be regulated by non-genetic mechanisms,

Free Research Field

腫瘍学

Academic Significance and Societal Importance of the Research Achievements

この研究により、大腸の主な前がん病変である管状腺腫の生物学的多様性を有することが明らかになり、遺伝子変異以外の機序が寄与していることが示唆された。管状腺腫が単細胞からの増殖能を獲得することが前がん病変からのがん化に関与する可能性も考えられ、本研究の成果が大腸発がんのメカニズムの解明につながることが期待される。また前がん病変の生物学的な特性を理解することが、将来的な発がん予防法の開発につながることが期待され、重要な意義を有する。

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Published: 2023-01-30  

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