2021 Fiscal Year Final Research Report
Development of on-site coronary artery fluid analysis algorithm to predict plaque progression and failure
| Project/Area Number |
19K08488
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中村 匡徳 名古屋工業大学, 工学(系)研究科(研究院), 教授 (20448046)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 流体力学 / 有限要素法 / 冠動脈血流 |
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| Outline of Final Research Achievements |
The coronary flow reserve ratio (FFR) is used as an indicator to diagnose coronary ischaemia, but it is invasive; attempts have been made to estimate the FFR non-invasively using computational fluid dynamics (CFD), as exemplified by HeartFlow, but they are complex and time consuming; in this study Murray's law An attempt was made to estimate FFR by distributing blood flow based on the cubic ratio of the branch outlet vessel diameter and determining the outlet flow boundary condition, with peripheral vascular resistance modelled as electrical circuit resistance. By introducing a 0-dimensional model representing peripheral vascular resistance, it was found that appropriate flow distribution was possible for vessels without terminal stenosis, and FFRs close to the measured values were estimated.
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| Free Research Field |
数値流体力学
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| Academic Significance and Societal Importance of the Research Achievements |
今回の研究では冠動脈狭窄を非侵襲的に測定するアルゴリズムの一方法を新しく考案し検証を行った。本手法を用いると現在はスーパーコンピューターで数時間かかる演算が汎用のワークステーションで数十分で可能になる。計算の正確性や実臨牀データとの比較は今後の課題であるが、本手法の発展により日常診療で即日報告可能な形で冠動脈の機能的な狭窄度が算出されるため実臨床でも使用可能となることが期待できる。
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