Role of calcium/calmodulin-dependent protein kinase II and development of new treatment strategy for coronary spastic angina

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08530
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Hirosaki University
• Principal Investigator: Tomita Hirofumi 弘前大学, 医学研究科, 教授 (00431437)
• Co-Investigator(Kenkyū-buntansha): 花田 賢二 弘前大学, 医学部附属病院, 助教 (90632993)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 冠攣縮

Outline of Final Research Achievements

In the present study, we demonstrated the inhibitory effects of carvedilol and diltiazem on coronary spasm in mouse models of coronary spastic angina. Furthermore, we performed in vitro experiments to further investigate its mechanism, and found intracellular signaling pathways and a novel molecule associated with coronary spasm. The present study may help better understand mechanism of the coronary spasm and contribute to the development of a novel treatment strategy for coronary spastic angina.

Free Research Field

循環器内科学

Academic Significance and Societal Importance of the Research Achievements

冠攣縮は異型狭心症のみでなく、一部の労作狭心症や急性心筋梗塞症、突然死の病態にも関与する。冠攣縮性狭心症の治療薬としてカルシウム拮抗薬が用いられているものの、カルシウム拮抗薬抵抗性の難治性冠攣縮性狭心症患者も少なくなく、治療に難渋する場合も多い。本研究により冠攣縮性狭心症の新しい機序解明のみならず、カルシウム拮抗薬治療抵抗性の難治性冠攣縮性狭心症の機序解明ならびにその治療法開発への応用が期待される。