2022 Fiscal Year Final Research Report
Basic research to elucidate the function of the novel cytokine IL-38 and development of new therapeutic agents
| Project/Area Number |
19K08636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53030:Respiratory medicine-related
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | IL38 |
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| Outline of Final Research Achievements |
A model of acute lung injury caused by bleomycin (BLM) was created and compared between the control and IL-38KO mouse groups, with the expectation that the degree of lung injury would be stronger than usual in the IL-38KO group.
BLM 20 μg was administered intratracheally, and cell count and fractionation measurements of BAL fluid on Day 21 and serum IL-38, TNFα, TGFβ, IL-4, IL13, IL-18, IL-1b, IL-17, IL-38, IL-13, IL-18, IL-1b, and IL-17 were measured. No significant differences were observed between the WT and IL38KO groups. However, the degree of inflammatory cell infiltration in the IL-38KO group was slightly less than that in the WT group.
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| Free Research Field |
呼吸器科
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| Academic Significance and Societal Importance of the Research Achievements |
IL38は活動性の高い間質性肺疾患で高発現していることをすでに発表した。そこで間質性肺疾患の線維化に対しIL38がどのように関与しているか調べるための実験であり、IL-38KO群では通常より肺障害の程度が強くなると予想していた。しかし、予想に反して炎症性サイトカインにWTとIL38KO群とで有意差を認めず、組織ではIL-38KO群で炎症細胞浸潤の程度がやや軽かった。IL38は、線維化が進んでしまうと発現は低下していたが、間質性肺疾患の活動性の炎症の時期においても、その時期によって発現に差があるのではないかと推測している。
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