Basic research of the significance of clock gene DEC1 decreases in chronic kidney disease progression

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K08710
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Shizuoka Cancer Center Research Institute
• Principal Investigator: Sato Fuyuki 静岡県立静岡がんセンター(研究所), その他部局等, 研究員 (60400131)
• Co-Investigator(Kenkyū-buntansha): 村垣 泰光 和歌山県立医科大学, 医学部, 博士研究員 (40190904) ; 藤本 勝巳 広島大学, 医系科学研究科(歯), 助教 (40294566) ; Bhawal Ujjal 日本大学, 松戸歯学部, 講師 (50433339) ; 及川 恒輔 和歌山県立医科大学, 医学部, 講師 (70348803)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 時計遺伝子 / 慢性腎不全 / DEC1 / 免疫染色

Outline of Final Research Achievements

We examined the significant role of clock gene DEC1 decreases in chronic kidney disease (CKD) progression. The DEC1 decreases was observed in kidneys of CKD case autopsy, aged and klotho (klo) mutant mice. On the other hand, ASMA expression was increased. In klo mutant mice, circadian rhythm was disturbed and the DEC1 expression was decreased, but ASMA was increased. The DEC1 decreases and ASMA increases were observed in human kidney cultured cells treated with hyperphosphatemia condition. These results suggest that DEC1 decreases and ASMA increases were closely associated with CKD progression and circadian rhythm disturbance.

Free Research Field

病理学

Academic Significance and Societal Importance of the Research Achievements

CKD進展における時計遺伝子DEC1の重要性を明らかにすることで、日内リズムの観点から、例えば、慢性的な睡眠不足の解消でDEC1発現が低下せず、CKD発症率が低下するなどを示せれば、CKD発症の予防への展開も期待され、CKD患者に対し、睡眠の質の向上を目指した生活習慣の改善の意識改革にも繋がる。