Toward a Model District for CKD Prevention Starting with Maternal and Child Health

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K08716
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Kurume University
• Principal Investigator: Kaida Yusuke 久留米大学, 医学部, 講師 (80441658)
• Co-Investigator(Kenkyū-buntansha): 深水 圭 久留米大学, 医学部, 教授 (80309781)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: アルブミン尿 / ３歳児健診

Outline of Final Research Achievements

Through November 2023, the study enrolled 1227 patients with a median UAE of 9.4 mg/g.cre; 58 (4.7%) had a UAE ≧30 mg/g.cre. Multivariate logistic regression analysis showed that risk factors for microalbuminuria were significantly associated with higher maternal prepregnancy BMI (OR 1.14; 95% CI, 1.07-1.21), suggesting a possible role of maternal prepregnancy obesity in the development of microalbuminuria in 3-year-old children. The results suggest that maternal pre-pregnancy obesity may play a role in the development of trace albuminuria in 3-year-old children.

Free Research Field

腎臓内科学

Academic Significance and Societal Importance of the Research Achievements

本研究では、3歳児における尿中アルブミン排泄の増加に母体環境（特に肥満）が関与していることが明らかになった。今後、産科や小児科などと連携しながら胎児期からのCKD予防につなげていきたい。