Effects of phototherapy and phosphodiesterase 4 inhibition on psoriasis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08758
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Teikyo University
• Principal Investigator: Kamata Masahiro 帝京大学, 医学部, 准教授 (70431856)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 乾癬 / 光線療法 / ホスホジエステラーゼ４ / 制御性T細胞 / 制御性B細胞 / IL-17

Outline of Final Research Achievements

Psoriasis is a chronic inflammatory skin disease characterized by indurated scaly erythema spreading over the whole body. The effects of phototherapy and phosphodiesterase (PDE)-4 inhibition on psoriasis remained to be elucidated. We investigated their mechanism of action, utilizing murine imiquimod-induced psoriasiform dermatitis. Both narrow band UVB irradiation and an PDE-4 inhibitor downregulated IL-17 mRNA expression in the lesional skin. Narrow band UVB irradiation induced regulatory T cells in the lesional skin, whereas the PDE-4 inhibitor induced splenic regulatory B cells and regulatory T cells. This difference in the mechanism may account for synergistical effectiveness of phototherapy and PDE-4 inhibition for psoriasis.

Free Research Field

乾癬

Academic Significance and Societal Importance of the Research Achievements

本研究により、光線療法とホスホジエステラーゼ(Phosphodiesterase; PDE) 4阻害薬の乾癬いおける作用機序が明らかになった。また、光線療法とアプレミラストに相乗効果があることが報告されていたが、その理由についても機序の違いから明らかになった。