The reality of individual aging promoted by the endogenous aging of the skin, and the possible reversibility by anti-inflammatory interventions.

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08778
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: University of the Ryukyus
• Principal Investigator: TAKAHASHI KENZO 琉球大学, 医学(系)研究科(研究院), 教授 (80291425)
• Co-Investigator(Kenkyū-buntansha): 山口 さやか 琉球大学, 病院, 講師 (70571397) ; 内海 大介 琉球大学, 医学部, 特命助教 (40551958)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 皮膚科学 / 加齢医学 / 慢性炎症 / 表皮 / 免疫抑制

Outline of Final Research Achievements

The expression of Cox1 and caspase 1 and the early response genes cluster is enhanced in the skin of aged mice, and is also induced in young mice by transfer of serum factors in parabiosis. Gene expression of CCL11 in skin is also enhanced with aging, and this expression level is was sufficient compared to other secreted proteins derived from epidermis. The persistence of micro chronic inflammation in the skin is understood as a continuum from skin damage to aging.
Anti-TNFa antibodies and COX2 inhibitors have been shown to release the upregulation of some early genes, COX2, and CCL11. The results suggest that aging phenomena in each organ, which have been explored individually, are in fact interrelated within an individual, and that individual aging progresses in a summative manner.

Free Research Field

皮膚科学

Academic Significance and Societal Importance of the Research Achievements

マウスの各臓器の老化現象が個体内では相互に関連し、総和的に個体の老化が進行する事が理解された。加齢したマウスの皮膚において、外的因子による老化病態と内因性因子による老化現象は、必ずしも明確に区別できる現象ではなく、少なくとも一部は、互いにCOX2の誘導を伴う持続性の微小慢性炎症の帰結であることを明らかにした。抗ヒトの各臓器の老化は個別に進行するわけではなく、互いに相乗的に進行する現象であり、高齢者に生じる様々な老化現象や臓器機能の低下の多くが同根であり、少なくとも一部の進行は抑制可能であると考えられる結果である。