2023 Fiscal Year Final Research Report
The role of progranulin in the pathogenesis of inflammatory skin diseases
| Project/Area Number |
19K08788
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Asahi University (2022-2023)
Gifu University (2019-2021) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
水谷 陽子 岐阜大学, 医学部附属病院, 講師 (60759950)
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| Project Period (FY) |
2019-04-01 – 2024-03-31
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| Keywords | プログラニュリン / 乾癬 / アトピー性皮膚炎 / サイトカイン |
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| Outline of Final Research Achievements |
Serum PGRN (progranulin) concentrations were significantly increased in psoriasis compared to healthy subjects and were positively correlated with PASI (psoriasis area and severity index) score, a clinical marker of psoriasis. We also found a correlation with serum PGRN concentrations and serum IL-17 and IL-22 concentrations. PGRN concentrations were significantly higher in sera from patients with atopic dermatitis and correlated positively with TARC (thymus and activation-regulated chemokine) and IL-36γ concentrations.
The effects of PGRN on cultured epidermal cells were examined: IL-23 expression in epidermal cells was increased when PGRN was added to the culture medium. Furthermore, the expression of PGRN was significantly increased by the addition of IL-22, IL-36γ, and TNF-α to the culture medium. These results suggest that PGRN plays a role in the pathogenesis of psoriasis and atopic dermatitis via cytokines.
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| Free Research Field |
皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
プログラニュリンはサイトカイン産生を介して乾癬、アトピー性皮膚炎などの皮膚疾患の病態形成に関与することが明らかになり、今後の病態解明と創薬に役立つと考えられる。
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