2021 Fiscal Year Final Research Report
A role of remodelings of metabolism and epigenome code in the cellular senescence associated with chronic dermatitis
| Project/Area Number |
19K08792
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Ehime University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 慢性炎症 / 皮膚 / エピゲノム / 代謝 |
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| Outline of Final Research Achievements |
Our present study has been performed to unveil roles of metabolic and epigenetic remodeling in epidermal keratinocytes under chronic dermatitis settings. As results, we found that a TLR7 agonist could have regulated the expression of menin and that the deficiency of menin in keratinocytes led to dysregulations of layer-dependent expressions of epidermal structural proteins, proliferative responses, the expression of a glucose transporter, and the infiltration of immune cells in response to repeated applications of an antigen.
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| Free Research Field |
免疫学、皮膚科学
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| Academic Significance and Societal Importance of the Research Achievements |
がんや免疫細胞の先行研究で進みつつある慢性炎症とエピゲノム変化や代謝変化との関連性について、本研究では初めて表皮を対象に検討した。その結果、表皮の様な体細胞でも、エピゲノム変化関連因子の発現は、代謝状態の変化や炎症応答性の性状変化に関与することが示唆された。この発見は、長期間の加療を必要とする慢性皮膚疾患において、エピゲノムや代謝を標的とした創薬の研究基盤の構築に大いに貢献するものと考えられる。
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