2021 Fiscal Year Final Research Report
Role of NKG2D immunity in myelodysplastice syndrome
| Project/Area Number |
19K08821
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 54010:Hematology and medical oncology-related
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| Research Institution | Wakayama Medical University |
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Principal Investigator |
Sonoki Takashi 和歌山県立医科大学, 医学部, 教授 (30382336)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 骨髄異形成症候群 / NKG2D免疫 / 自己炎症性腸疾患 |
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| Outline of Final Research Achievements |
(1) Serum sNKG2DLs levels were measured in patients with myelodysplastic syndrome (MDS) and healthy subjects. Serum sNKG2DLs levels were lower in MDS patients than in healthy subjects. Previous reports have shown that serum sNKG2DLs were higher in aplastic anemia (AA) and paroxysmal nocturnal hemoglobinuria (PNH) patients with bone marrow failure than in normal subjects. These results suggest that serum sNKG2DL levels may be useful in differentiating MDS from AA and PNH. (2) We identified a new genetic mutation in a patient with MDS and created a mouse model. These mice developed hematopoietic failure and enteritis. We confirmed that abnormal blood cells are important in the development of enteritis.
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| Free Research Field |
血液内科
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| Academic Significance and Societal Importance of the Research Achievements |
骨髄異形成症候群（MDS）は、高齢者に好発する難治性血液疾患で、血球数低下をきたし、時に自己炎症性疾患を併発する。MDSの血球数低下には免疫介在性細胞障害が関与している。私達はMDSにおけるNK免疫の関与を調べるために、患者血清のNKG2Dリガンド値を調べた。その結果、MDS患者の血清NKG2Dリガンド値は健常人よりも低値であることがわかった。この結果は血球数低下をきたす類似疾患（再生不良性貧血や発作性夜間血色素尿症）と異なっており、鑑別診断に有用である。また、MDSのモデルマウスを作成したところ、血球数低下の他、自己炎症性腸炎を発症した。このマウスはMDSの免疫病態を調べる上で有用である。
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