Roles of angiocrine system in the process of engraftment after hematopoietic stem cell transplantation

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08858
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Takahashi Satoshi 東京大学, 医科学研究所, 特任教授 (60226834)
• Co-Investigator(Kenkyū-buntansha): 服部 浩一 順天堂大学, 大学院医学研究科, 特任先任准教授 (10360116)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 血管内皮細胞 / アンジオクライン / 細胞・組織 / シグナル伝達 / 生体分子 / 造血幹細胞増幅 / 造血幹細胞生着 / 造血幹細胞移植

Outline of Final Research Achievements

The graft failure and the infections after cord blood transplantations are major side effects. This study focuses on myeloid tissue-specific vascular endothelium and conducts basic research aimed at overcoming engraftment failure and promoting hematopoietic recovery with a novel approach. In other words, our group confirmed that hematopoietic stem cell proliferation and differentiation can be promoted by molecules released from vascular endothelial cells as indicated in previous research by the research coordinators in disease animal models, cell transplantation models, etc. We clarified the proliferative ability of hematopoietic cells on adult vascular endothelial cells and the details of vascular endothelial hematopoietic conversion in adults. Our study suggests the effectiveness of co-transplantation therapy with vascular endothelial cells to prevent or reduce engraftment failure and accelerate hematopoietic recovery, which are two important issues for cord blood transplantation.

Free Research Field

血液腫瘍内科

Academic Significance and Societal Importance of the Research Achievements

造血発生過程で認められる血管内皮造血転換を成体細胞―血管内皮細胞の潜在能力と捉えて、生体恒常性維持あるいは血管内皮細胞と造血幹細胞との相互作用の解明から、血管内皮細胞の移植医療への活用へと展開した本研究成果は、臍帯血移植の安全性と有効性を高め、移植患者の生命予後の改善につながる他、再生不良性貧血等の他疾患の新しい視点からの病態解明、さらには老化に伴う生体変化機構の解明等の副次的な成果を得ることとなった。