Rab controls allergic diseases viaregulating autophagy

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K08909
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Ehime University
• Principal Investigator: Suzuki Junpei 愛媛大学, 医学系研究科, 助教 (20734239)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: Rab / オートファジー / アレルギー性疾患

Outline of Final Research Achievements

Th2 cells and IL-33R-Th2 cells induces allergic diseases by producing Th2 cytokines. This study shows that Rabs inhibited the induction of differentiation of Th2 cells and IL-33R-Th2 cells. It has been reported that autophagy is regulated by Rabs. The differentiation of Th2 cells and IL-33R-Th2 cells was suppressed by inhibition of autophagy. These results suggested that Rab regulated the induction of Th2 and IL-33R-Th2 cell differentiation via controlling autophagic flux. The regulation of Rabs and autophagy might be a novel therapeutic target molecules for allergic diseases.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

Th2細胞やIL-33R-Th2細胞分化におけるRabの役割やオートファジーの役割は十分に理解されていない。本研究により、Rab分子群の中からTh2細胞分化やIL-33R-Th2細胞分化の制御に関わるRab分子を3つ同定した。さらに、Rabを介したオートファジーの調節がTh2細胞分化やIL-33R-Th2細胞分化を制御する可能性を新たに見出した。