2021 Fiscal Year Final Research Report
Elucidation of pathophysiology and development of new treatments with the neurotransmitter dopamine for rheumatoid arthritis
| Project/Area Number |
19K08926
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 54020:Connective tissue disease and allergy-related
|
|---|
| Research Institution | University of Occupational and Environmental Health, Japan |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
田中 良哉 産業医科大学, 医学部, 教授 (30248562)
|
|---|
| Project Period (FY) |
2019-04-01 – 2022-03-31
|
| Keywords | ドパミン受容体シグナル |
|---|
| Outline of Final Research Achievements |
It has been reported that the nervous system and neurotransmitters affect not only the immune system but also bone metabolism. Dopamine, a typical neurotransmitter, revealed that dopamine is abundant in the dendritic cells of the inflammatory synovium of patients with rheumatoid arthritis. Furthermore, it was clarified that the dopamine D2 receptor signal suppresses the formation of osteoclasts by suppressing the intracellular cAMP-c-Fos-NFATc1. Based on these results, we investigated the possibility that neurotransmitters could be a new treatment method for rheumatoid arthritis, and a new treatment method for rheumatoid arthritis with neurotransmitters.
|
| Free Research Field |
膠原病リウマチ内科学
|
| Academic Significance and Societal Importance of the Research Achievements |
我々の結果からは、炎症性サイトカイン抑制・骨吸収抑制による影響は考えられ、cAMP応答配列を介したwntシグナル修飾も近年報告されており、ドパミンシグナルによるcAMPを介した骨芽細胞形成への直接的な影響も考えられる。ドパミンシグナルによる骨破壊病態への治療応用を想定した際に、骨代謝に対するメカニズムの解明は必須であり、本研究は新規治療への展開にとどまらず、神経と骨免疫のクロストークを解明するブレークスルーとしての可能性を有するため、医学的にも社会的にも多大な意義を持つものと考える。
|
