Mechanism of recurrence progression after hepatectomy in non-alcoholic steatohepatitis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09095
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55010:General surgery and pediatric surgery-related
• Research Institution: The University of Tokushima
• Principal Investigator: YAMADA Shinichiro 徳島大学, 病院, 特任助教 (30579884)
• Co-Investigator(Kenkyū-buntansha): 齋藤 裕 徳島大学, 病院, 講師 (50548675) ; 森根 裕二 徳島大学, 大学院医歯薬学研究部(医学域), 准教授 (60398021) ; 居村 暁 徳島大学, 病院, 特任教授 (90380021)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: NASH / 肝切除

Outline of Final Research Achievements

The aim of this study was to investigate the mechanism of progressed hepatocarcinogenesis after hepatectomy in NASH. However, model of NASH carcinogenesis could not be established. So, colon cancer liver metastasis model after hepatectomy in NASH was investigated. Tumor diameter was significantly smaller in NASH liver than normal liver after hepatectomy. Furthermore, expressions of IL-6 and SAA1 mRNA were significantly lower in NASH liver compared with normal liver. From these findings, liver metastasis was suppressed after hepatectomy in NASH liver due to suppressed metastatic niche.

Free Research Field

大腸癌肝転移　肝切除　非アルコール性脂肪肝炎

Academic Significance and Societal Importance of the Research Achievements

近年食生活の欧米化に伴い、非アルコール性脂肪肝炎(NASH)の罹患率は急激に増大している。大腸癌肝転移の根治は外科手術が第一選択となるが、肝転移形成におけるNASHの影響については未だ不明な点が多い。本研究によりそのメカニズムを解明することは、今後増加するであろうNASH肝の転移巣切除の可否等の決定に重要な役割を果たすと考えられる。