Novel diagnostic methods for invisible pancreas cancer

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09168
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55020:Digestive surgery-related
• Research Institution: Nagoya University
• Principal Investigator: WATANABE Nobuyuki 名古屋大学, 医学部附属病院, 助教 (20746903)
• Co-Investigator(Kenkyū-buntansha): 梛野 正人 名古屋大学, 医学系研究科, 教授 (20237564) ; 江畑 智希 名古屋大学, 医学系研究科, 教授 (60362258) ; 横山 幸浩 名古屋大学, 医学系研究科, 特任教授 (80378091) ; 國料 俊男 名古屋大学, 医学部附属病院, 病院准教授 (60378023) ; 山口 淳平 名古屋大学, 医学部附属病院, 病院講師 (00566987)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: invisible膵癌 / エクソソーム / バイオマーカー

Outline of Final Research Achievements

Exosomes isolated from KLM1 (human pancreatic cancer cell line), were involved in the proliferation and motility. Angiogenesis array revealed the several proteins concerning angiogenesis and motility in exosomes of KLM1. However, these proteins were not identified in bile exosomes. Since KLM1 is a cell line derived from human pancreatic cancer and bile is derived from biliary tract cancer patients, the results were considered to be due to the difference in cancer type. Although further investigation is required, the identified proteins may be markers of pancreatic cancer-specific exosomes.

Free Research Field

消化器外科

Academic Significance and Societal Importance of the Research Achievements

膵癌特異的なエクソソームのマーカーになる可能性のある血管新生、運動能に関与するタンパクを同定した。これらのタンパクはinvisible膵癌の診断治療法の開発のための重要な知見であり学術的意義が大きい。本研究により新規治療法開発の可能性が示唆され、実用化されれば、治療成績の向上が期待され社会的意義は大きい。