2021 Fiscal Year Final Research Report
Searching new immunotherapy for Crohn's disease by T cell inactivation using anal canal specimens
| Project/Area Number |
19K09223
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55020:Digestive surgery-related
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| Research Institution | Nara Medical University |
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Principal Investigator |
Kuge Hiroyuki 奈良県立医科大学, 医学部, 講師 (30801774)
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| Co-Investigator(Kenkyū-buntansha) |
岩佐 陽介 奈良県立医科大学, 医学部附属病院, 研究員 (30812317)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | クローン病 |
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| Outline of Final Research Achievements |
It was not possible to create concrete research results. The leading causes are small intestinal fistula stenosis and CD disease-related carcinogenic surgery, and the number of anal lesion surgery was small, and it was not possible to collect anal samples. Biologics such as Remicade. The reason is that the control rate of anal lesions is increasing and the number of cases of CD anal lesion surgery in the hospital specializing in anal disease is decreasing. The clinical database of CD can be created at the same time, and the clinical severity (IOIBD , CDAI) and clinical information can be compared quickly.
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| Free Research Field |
大腸肛門外科
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| Academic Significance and Societal Importance of the Research Achievements |
難治性炎症性腸管障害クローン病は長期間の慢性経過を辿り再燃寛解を繰り返す原因不明の炎症性腸疾患で若年発症例が多い．クローン病肛門病変特異的かつ新規治療法開発はクローン病に悩む患者にとって福音となる．
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