2021 Fiscal Year Final Research Report
Investigating the mechanism of functional recovery mediated by the transplantation of cardiosphere-derived cell and developing the cell-free regenerative medicine for heart failure.
| Project/Area Number |
19K09246
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55030:Cardiovascular surgery-related
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| Research Institution | Yamaguchi University |
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Principal Investigator |
Suzuki Ryo 山口大学, 大学院医学系研究科, 助教 (10570319)
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| Co-Investigator(Kenkyū-buntansha) |
美甘 章仁 山口大学, 大学院医学系研究科, 准教授 (30372709)
濱野 公一 山口大学, 大学院医学系研究科, 教授 (60263787)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Keywords | 心筋幹細胞 (CDCs) / エクソソーム / 慢性心不全 / 陳旧性心筋梗塞 / 低酸素プレコンディショニング |
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| Outline of Final Research Achievements |
The number of patients with heart failure is increased, and ischemia accounts for almost half of cases. Due to the shortage of donor, cardiac transplantation is hardly performed to rescue the patients with advanced heart failure. Although the transplantation of stem cells was believed to be the alternative for this therapy, its clinical application may be difficult due to the vast amount of time and cost.
Recently, exosomes has emerged as a new candidate for the regenerative medicine, since they are easy to handle and play an important role in mediating functional repair. In the present study, we showed that administration of exosomes activated by the hypoxic preconditioning could ameliorate the cardiac dysfunction in a heart failure model with old myocardial infarction. Our data revealed that exosomes contained VEGF and activated MMP in RAW264 cells, suggesting that they induce angiogenesis and reduce fibrosis which could protect the heart from maladaptive remodeling.
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| Free Research Field |
心臓血管外科
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| Academic Significance and Societal Importance of the Research Achievements |
OMIモデルのような慢性心不全の病態ではCDCs由来エクソソームの心筋保護は明らかになっておらず、不明な点が多かった。我が国で増加する慢性心不全の新規治療法を開発する意味でもこれを検討する価値は高く、学術的・社会的意義があると考えられた。今回の検討で、心筋幹細胞由来エクソソームによる治療応用の可能性が示された。
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