Prevention strategies for perioperative neuroinflammation related diseases with a focus on stabilization of intestinal microbiota

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09331
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Sapporo Medical University
• Principal Investigator: Yamakage Michiaki 札幌医科大学, 医学部, 教授 (70285005)
• Co-Investigator(Kenkyū-buntansha): 立花 俊祐 札幌医科大学, 医学部, 助教 (30737309) ; 西原 教晃 札幌医科大学, 医学部, 研究員 (70836436)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 神経麻酔 / せん妄 / 腸内細菌叢 / 行動変化

Outline of Final Research Achievements

In a metagenomic analysis of cecal contents collected under anesthesia after surgical intervention, we were unable to explore significant changes between the groups. It was suggested that the timeline of intervention and other factors need to be re-examined. While the composition of the cecal contents was not acutely altered, we did find changes in delirium behavior in the surgical group, with no significant differences between groups. Additional experiments are planned.

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Free Research Field

神経麻酔学

Academic Significance and Societal Importance of the Research Achievements

ヒトにおけるせん妄予防の実証研究、特に術後のせん妄の解決手段として、腸内細菌叢の改善を狙った戦略を立てる上でのヒントが得られたものと考える。