Mechanisms and implications of metabolic reprogramming of immune cells in the perioperative inflammatory response

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09339
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kansai Medical University
• Principal Investigator: MATSUO Yoshiyuki 関西医科大学, 医学部, 講師 (50447926)
• Co-Investigator(Kenkyū-buntansha): 広田 喜一 関西医科大学, 医学部, 教授 (00283606)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 炎症 / 代謝 / ミトコンドリア

Outline of Final Research Achievements

To elucidate the molecular mechanisms of metabolic reprogramming associated with innate immune cell activation, we examined the gene expression profiles and metabolic properties of macrophages in response to inflammatory stimuli. With the induction of inflammatory markers related to macrophage differentiation, cellular oxygen consumption was suppressed in activated macrophages, indicating the metabolic shift from the oxidative phosphorylation to the glycolytic pathway. The activities of mitochondrial respiratory complexes were left intact after induction of metabolic reprogramming associated with inflammation, and the results suggest the involvement of alterations of cellular redox homeostasis.

Free Research Field

ストレス応答

Academic Significance and Societal Importance of the Research Achievements

炎症応答において免疫細胞のエネルギー代謝様式の転換（リプログラミング）が起こることが報告され、炎症の制御メカニズムとして細胞内代謝調節の重要性に注目が集まっている。炎症の発生・進展・収束と連動した代謝変換をコントロールする機構の詳細を明らかにすることは、複雑な炎症シグナルの総合的理解、さらには代謝制御を標的とした治療・診断法の開発に繋がることが期待される。