The clarifiy the mechinism of postoperative cognitive dysfunction in the elderly rats

2023 Fiscal Year Final Research Report

• Project/Area Number: 19K09345
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Gunma University
• Principal Investigator: kadoi Yuji 群馬大学, 医学部附属病院, 准教授 (10292591)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Keywords: 術後認知機能障害 / アミロイドタンパク

Outline of Final Research Achievements

We examined where region in beta-amyloid protein was more found in the brain in elder rats. CA1 region was more often observed in elder rats, compared with that in young rats. We examined the effects of dexmedetomide on the decrease in the amount of beta-amyloid protein in CA1 region, and failed the show that no effects of dexmedetomidie was found the decrease in the amount of beta-amyloid protein in CA1 region.

Free Research Field

麻酔・集中治療

Academic Significance and Societal Importance of the Research Achievements

高齢者での手術後の認知機能障害発症の原因究明と治療は早急な課題である。今回の研究において高齢ラットでは侵襲によってCA1領域においてより多くのβ amyloid proteinの発現を観察したことは認知機能障害の原因のいったんとして解明できた。その認知機能障害をデクスメデトミジンにより改善可能かどうかを行ったが残念ながら改善は出来ず、今後の課題となった。