Studies on automatic drug-administration control systems during anesthesia and perioperative period

2022 Fiscal Year Final Research Report

• Project/Area Number: 19K09354
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55050:Anesthesiology-related
• Research Institution: Kagawa University
• Principal Investigator: Shirakami Gotaro 香川大学, 医学部, 教授 (20235740)
• Project Period (FY): 2019-04-01 – 2023-03-31
• Keywords: 麻酔薬 / 鎮静薬 / 筋弛緩薬 / 血糖値 / 自動制御 / 筋弛緩度指標 / 痛み度指標 / 鎮静度指標

Outline of Final Research Achievements

In order to develop automatic drug infusion systems during anesthesia and perioperative period, we performed clinical investigations concerning levels of sedation-analgesia, muscle relaxation and blood glucose as control targets. We tried to construct mathematical models describing the relations between dose of remimazolam, a new sedative agent, and sedation index, between dose of rocuronium, a muscle relaxant, and muscle relaxation index, and between doses of insulin/glucose and blood glucose level in patients entering an intensive care unit after major surgery. We showed that they can be applicable for the automatic control systems.

Free Research Field

麻酔科学

Academic Significance and Societal Importance of the Research Achievements

本研究は麻酔・周術期管理方法の質向上、在院期間短縮や予後改善、周術期管理に関係する医療スタッフの業務負担軽減に貢献することが期待される。また、薬剤投与自動制御システムの開発は学術的意義のみならず新産業発展の端緒となる可能性がある。