New therapeutics for targeting vascular remodeling in sepsis

2021 Fiscal Year Final Research Report

• Project/Area Number: 19K09399
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 55060:Emergency medicine-related
• Research Institution: University of Miyazaki
• Principal Investigator: Yano Takeshi 宮崎大学, 医学部, 講師 (80521707)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Keywords: 敗血症

Outline of Final Research Achievements

Remodeling also plays an important role in the new coronavirus infection (COVID-19) and may have a significant impact on patients. The results of this study suggested that severe cases of COVID-19 frequently had a history of smoking and comorbidities, suggesting that the older the patient, the more the need for mechanical ventilation and the increased risk of death. It was also observed that the patient background and severity changed depending on the vaccination and the type of mutant strain. Although mechanical ventilation is essential for the treatment of COVID-19 severe pneumonia, it may also be a risk of ICU-AW and delirium. Further studies are needed on the possibility that COVID-19 and multimodal therapy may lead to prolonged dysfunction.

Free Research Field

救急医学

Academic Significance and Societal Importance of the Research Achievements

未だ感染拡大を続ける新型コロナウイルス感染症（COVID-19）に関して、日々の報道によって膨大な情報が溢れる一方で、刻々と変わる情勢や流行株の変異に伴って診療状況は常に変化しており、正確な状況判断のためには詳細な現状分析が必要である。またCOVID-19では様々な後遺障害が問題となるが不明な部分が多い。本研究成果より高齢者のリスクが高いことが再確認され、また集学的治療そのもののリスクも考慮する必要が推察された。研究成果がCOVID-19や重症患者管理の一助となることを期待したい。