2022 Fiscal Year Final Research Report
A investigation of a role of remote organ failure after tissue injury using our new tissue injury model.
| Project/Area Number |
19K09405
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 55060:Emergency medicine-related
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
増野 智彦 日本医科大学, 医学部, 講師 (00318528)
吉野 由希子 日本医科大学, 大学院医学研究科, 研究生 (80813097)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Keywords | 骨軟部組織損傷 / 臓器障害 |
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| Outline of Final Research Achievements |
In severe trauma, a significant systemic inflammatory response occurs early in the course of injury. Recent studies have revealed that tissue damage and endogenous factors released by tissue damage play a pivotal role in the development of the systemic inflammatory response after severe trauma.
We have developed a model of soft tissue injury (TBX model) with the addition of hemorrhagic shock (two-hit model). In the TBX model, the systemic inflammatory changes in the early phase (after 3 hours) of soft tissue injury alone (TBX transplantation) or hemorrhagic shock + resuscitation alone were mild. On the other hand, the synergistic effect of soft tissue injury (TBX transplantation) combined with hemorrhagic shock and resuscitation resulted in a severe systemic inflammatory response. These results support the two-hit theory proposed previously and suggest that the two-hit model we used is a useful model for future studies to clarify the mechanism of organ damage that occurs after trauma.
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| Free Research Field |
生体侵襲学、外傷学
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| Academic Significance and Societal Importance of the Research Achievements |
重症外傷後引き続く臓器障害のため死にいたる症例に対し、臓器障害発生メカニズムの機序解明、さらにそれに基づく治療法の開発は、今後の外傷治療に大きく貢献できると考える。今回の研究成果は、まだ検体数少ないということ、経時的な炎症反応の変化を見るにいたってないため、今後、さらなる研究の継続を行うべきであろうと考える。
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